Shibata, Takanori, Tadakatsu Hayase, Jun Yamamoto, and Kenso Soai. “One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess.” Tetrahedron: Asymmetry 8, no. 11 (1997): 1717-1719.
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A trace amount (ca. 3 mg) of 2-methylpyrimidyl alkanol with only a slight enantiomeric excess (0.2 – 0.3% e.e.) was auto-multiplied with dramatic amplification of enantiomeric excess (up to ca. 90% e.e.) in one-pot asymmetric autocatalytic reaction using diisopropylzinc and 2-methylpyrimidine-5-carbaldehyde.
A pyrimidyl alkanol with low e.e. is auto-multiplied with dramatic increase in the amount and e.e. in a one-pot asymmetric autocatalytic reaction.