Takagi, Hiroaki, and Kunihiko Kaneko. “Differentiation and replication of spots in a reaction-diffusion system with many chemicals.” EPL (Europhysics Letters) 56, no. 1 (2001): 145.
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The replication and differentiation of spots in reaction-diffusion equations are studied by extending the Gray-Scott model with self-replicating spots to include many degrees of freedom needed to model systems with many chemicals. By examining many possible reaction networks, the behavior of this model is categorized into three types: replication of homogeneous fixed spots, replication of oscillatory spots, and differentiation from “multipotent spots” . These multipotent spots either replicate or differentiate into other types of spots with different fixed-point dynamics, and, as a result, an inhomogeneous pattern of spots is formed. This differentiation process of spots is analyzed in terms of the loss of chemical diversity and decrease of the local Kolmogorov-Sinai entropy. The relevance of the results to developmental cell biology and stem cells is also discussed.